The concerning side effect of Ochronosis is very rare, and associated with long term use of high doses of Hydroquinone such as 6-8%. The TTForte (we no longer sell this product) contains 2%, and includes instructions to be used for short periods of time. 

According to the Natural Center for Advancing Translational Sciences, Ochronosis is the bluish-black or grey-blue discoloration of the skin, especially the ear cartilage, the ocular (eye) tissue, and other body locations. It can occur in individuals with alkaptonuria, an inherited metabolic disorder; or because of exposure to various substances. Ochronosis associated with alkaptonuria is caused by a genetic change in the HGD gene, which results in the accumulation and deposition of homogentisic acid (HGA) in cartilage. The affected tissue becomes weak and brittle with time, leading to chronic inflammation, joint pain, and osteoarthritis.

Facilities with a medical license can still sell the product (NAC) however the processing facilities and vendors that we purchase from will need to make changes if they want to continue producing.